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Leuchs' anhydride is an N-carboxyanhydride (NCA) first synthesized in 1906 by Hermann Leuchs, a German chemist. ==Synthesis== Leuchs' anhydride was first synthesized by reacting an N-ethoxycarbonyl or N-methoxycarbonyl amino acid chloride in a vacuum at 50-70 °C. Leuchs at al. prepared this reaction for the purpose of stepwise peptide synthesis. However, upon heating cyclization was observed and the reaction yielded NCAs and alkylchlorides. Synthesis of original Leuchs' anhydride (small pic) This synthesis of NCAs was deemed the . The relatively high temperatures necessary for this cyclization resulted in the decomposition of several NCAs. Therefore, Leuchs proposed several improvements in later years. One notable procedure involves reacting an unprotected amino acid with phosgene. AAtoLeuchsSyn 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Leuchs' anhydride」の詳細全文を読む スポンサード リンク
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